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30avril

MIM Dakar 2018 igrnores African pionneering research on Artemisia

Artemisia pas la bienvenue à la MIM Dakar

MIM was established in 1997 with a mission to strengthen the capacity of malaria-endemic countries in Africa to carry out research that is required to develop and improve tools for malaria control. It is thus surprising that none of the recent clinical trials carried out in several African countries by African doctors and universities, with Artemisia plants, which not only give cure rates close to 100%, eliminate gametocytes and transmission but also show stronger prophylactic properties than current antimalarial vaccines, that none of...

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01février

The dormancy effect of artemisinin and derivatives

L'artemisinine source de recrudescences paludiques

But treatment failures and first signs of resistance to artemisinin soon become evident like in China with arteannuin B and artemisin monotherapy. It was due to a novel effect: a small fraction of the parasites, as a result of chemotherapeutic pressure, become ‘dormant’. Indeed, it was common to administer very high doses up to 1 200 mg/person/day. At this stage, the parasite cycle is halted, making the parasites unsusceptible to further dosing until wakening. This slows down the antimalarial activity of the drug, entailing either many...

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09janvier

Cholesterol, phytosterols, malaria, chlorogenic acid and virus

Cholesterol und Phytosterole

The Plasmodium parasite needs cholesterol for survival and multiplication. This fact was well documented in a WHO document in 1977 and in subsequent papers George G. Holz, Jr. Lipids and the malarial parasite. Bull World Health Organ. 1977; 55(2-3): 237–248 Krishnegowda G, Gowda DC Intraerythrocytic Plasmodium falciparum incorporates extraneous fatty acids to its lipids without any structural modification. Mol Biochem Parasitol. 2003 Nov;132(1):55-8. Moll GN, Vial HJ, Ancelin ML, Op den Kamp JA, Roelofsen B, van Deenen L....

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09janvier

Polysaccharides and inulins: immunostimulants and adjuvants

Inulin stärkt das Immunsystem

Inulins and polysaccharides: immunostimulants and adjuvants. Host defense functions are responsive to diet composition. It is known since many years that inulin and oligofructose increase resistance to health challenges. Kelly-Quagliana, K.A., Nelson, P.D., Buddington, R.K. Dietary oligofructose and inulin modulate immune functions in mice. Nutr Res. 2003;23:257–267 The bioavailability of drugs with low aqueous solubility may be enhanced by inulin. Inulin has been used to produce solid dispersions or tablets of various poorly soluble...

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04novembre

CYP3A4, genetics, scopoletin

Facteurs génétiques du paludisme

CYP3A4, genetics and scopoletin. In a pionneering study in 2010, the University of Louvain had studied the anti-inflammatory effect and modulation of cytochrome P450 activities by Artemisia annua tea infusions in human intestinal Caco-2 cells Melillo de Magalhães, Yves-Jacques Schneider. Anti-inflammatory effect and modulation of cytochrome P450 activities by Artemisia annua tea infusions in human intestinal Caco-2 cell Food Chemistry 134(2):864-71 · September 2012 These assays were done on aqueous infusionsof Artemisia annua...

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Citation

L’homme nous passionne, sa diversité, ses histoires, ses savoirs, ses ignorances, sa compréhension du monde

Alexandre Poussin

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